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Men's Health

Testosterone for men

Everything we know about testosterone in the male body — the science, the studies, the symptoms, the delivery methods, and what real treatment looks like in 2026.

Clinical guides

56 articles

Written for a specific question. Start anywhere.

9 parts

Low testosterone symptoms

The symptoms that point to low-T, the biology behind each one, and how to tell symptom from coincidence — built around the Keen lab panel.

7 parts

Starting TRT

What actually happens from first blood test to a stable protocol — the timeline, the panels, what the numbers mean, and what good treatment looks like.

9 parts

Testosterone & cardiovascular safety

The evidence arc on TRT and heart risk — from TOM and Vigen through the FDA warnings to TRAVERSE and the 2025 labeling change.

5 parts

The TRAVERSE sub-studies

TRAVERSE answered more than the cardiovascular question. Prostate, bone, anemia, mood, and sexual function — what each nested study actually found.

7 parts

Landmark TRT clinical studies

Hudson, T4DM, Saad, the 41-RCT meta-analysis, the Endocrine Society guidelines — the non-cardiovascular trials that shape modern practice.

3 parts

Risks & monitoring

Hematocrit, fertility, and what happens above the physiological range — the side effects that need watching and the labs that catch them.

4 parts

How testosterone works

The HPG axis, protein binding and SHBG, and how a molecule crosses skin — the mechanisms underneath every other article here.

8 parts

Delivery methods & comparisons

Injections, gels, pellets, patches, sprays, microdosing — how each method performs pharmacokinetically, and how the options compare head to head.

4 parts

The history of testosterone therapy

How testosterone went from discovery to prescription to controversy — the market, the trials, and the arguments that shaped current practice.

The T Files

11 seasons · 55 episodes

A serialised history of testosterone, from a rooster experiment in the 1840s to the trials that finally answered the safety question. Read in order.

  1. OriginsBerthold's roosters, a 72-year-old injecting dog testes, and the monkey-gland craze. Where the idea of a male hormone came from.5
  2. Synthesis15,000 litres of urine, a perfume chemist, and a Nobel Prize almost nobody talks about. How testosterone was finally made.5
  3. InjectionsPropionate every three days, enanthate's fifty-year reign, POME, and the peak-and-crash problem that makes men quit in year one.5
  4. Gels and patchesThe scrotal patch that required hair clipping, a 48% skin-problem rate, AndroGel's billion-dollar run, and the boxed warning for transfer.5
  5. The cardiovascular scareThe 2010 study that scared everyone, the flawed meta-analysis behind the FDA warning, and how TRAVERSE finally answered the question.5
  6. MetabolismAromatase in the fat cell, the SHBG binding problem, and the bidirectional trap between low testosterone and body fat.5
  7. WomenWomen make testosterone too. The research gap nobody talks about, the ISSWSH and FDA standoff, and why dosing has to be different.5
  8. Male contraceptionThe WHO trials of the 1990s, DMAU, the NES/T gel that almost worked — and why male hormonal contraception still does not exist.5
  9. The sprayWhy skin is the most underrated route in medicine, the transfer problem with gels, and the clinical case for a metered transdermal spray.5
  10. The state of TRTFunctional hypogonadism, the lab work that actually matters, what good treatment looks like in 2026 — and 175 years from roosters to spray bottles.5
  11. The dose problemWhy the weekly shot leaves you feeling worse by day six, what happens above the physiological range, and what microdosing actually means in TRT.5

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