For Men
Men's Health
Evidence-based guides on testosterone optimization, TRT clinical science, delivery methods, low-T symptoms, and the comparisons that matter.
Evidence-based guides on testosterone optimization, TRT clinical science, delivery methods, low-T symptoms, and the comparisons that matter.
Everything we know about testosterone in the male body — the science, the studies, the symptoms, the delivery methods, and what real treatment looks like in 2026.
Coming soon.
Coming soon.
JAMA's review of adult male hypogonadism sets out the current diagnostic standard — two fasting morning samples, a threshold of 264 to 300 ng/dL, and free testosterone where SHBG is low. Its first-line treatment for the most common cause is not testosterone.
4 min readBasaria's Lancet seminar on male hypogonadism is best remembered for its contraindications — prostate and breast cancer, uncontrolled heart failure, severe urinary symptoms, and erythrocytosis. The list has aged better than most of the decade around it.
3 min readTOM was halted when 23 men on testosterone had cardiovascular adverse events against 5 on placebo. Its authors wrote that the trial's size and population prevent broader inferences. That sentence is usually left out.
4 min readA cardiovascular warning went into the Boxed Warning on every testosterone product on the strength of contested evidence. It took an FDA-mandated trial in 5,200 men to take it back out.
4 min readThe cardiovascular language came out of the Boxed Warning. A blood pressure warning went in. The age-related hypogonadism limitation stayed — until a further FDA request in June 2026 removed it.
4 min readTRAVERSE answered a question thirteen years of studies could not, because of four design choices made before a single man was enrolled — including one that made a null result meaningful rather than merely unproven.
4 min read