Women's Health
Progesterone
Why systemic estrogen is prescribed with a progestogen, which progestogens the evidence distinguishes between, and why the route of administration decides whether endometrial protection happens at all.
Why systemic estrogen is prescribed with a progestogen, which progestogens the evidence distinguishes between, and why the route of administration decides whether endometrial protection happens at all.
In 80,377 postmenopausal women followed for eight years, estrogen combined with progesterone carried a relative risk of 1.00 for breast cancer. Estrogen combined with other progestagens carried 1.69. The estrogen was the same; the progestogen was not.
4 min readA woman with a uterus taking systemic estrogen needs a progestogen to protect the endometrium. A systematic review of micronized progesterone found oral dosing protects, vaginal dosing may protect — and transdermal progesterone does not.
3 min read