Women's Health
Estrogen
Menopause hormone therapy: what the evidence supports treating, why the route of estrogen changes clot risk, and what the WHI actually found.
Menopause hormone therapy: what the evidence supports treating, why the route of estrogen changes clot risk, and what the WHI actually found.
On 10 November 2025 the FDA began removing the boxed warnings on menopausal hormone therapy for cardiovascular disease, breast cancer and probable dementia. One boxed warning stays: endometrial cancer, on systemic estrogen-alone products. That exception is the clinically important half of the story.
August 20, 20264 minGuideEstrogen